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Genome Microarray

This is a technique to analyze DNA sequence variants or structural changes.

SNP Genotyping Microarray

For the human genome composed of about 3 billion pairs of bases, most DNA sequences of individuals match, but about 0.1% is SNP (Single Nucleotide Polymorphism), which is where the differences lie. Such SNP causes genetic diversity of an individual and the difference of sensitivity to different diseases. With the SNP Genotyping Microarray, millions of SNPs can be analyzed simultaneously. Macrogen has the largest SNP chip data automation production facilities in Korea and provides accurate results by applying strict data quality control processes.

CGH Microarray

CNV (Copy Number Variation) means the DNA variation that a certain sequence section more than 1Kb is lost or amplified and repeated in the chromosome. Such copy number variation can cause various genetic diseases, as well as the proliferation of cancer cells. When analyzing CGH chip data, you can find the CNV that is the cause of diseases or specific phenotypes by using databases such as DGV and ClinVar, and CNV on genes and chromosomes can be analyzed using the CGH Microarray. Our CGH microarray systems allow us to select products according to the needs of our clients while providing CNV verification services for cell lines used in therapy.

Epigenome Microarray

This method quantifies and analyzes the level of methylation of numerous DNA sites at the same time.

DNA Methylation Microarray

DNA methylation is a chemical transformation that controls gene expression. This phenomenon of methyl generated in cytosine at the CpG site exists around the promoter region of a gene. If the cause of a disease or phenotype is a change in the methyl group of a specific CpG site, then statistical analysis between groups can be used to identify the location of the CpG site within the entire DNA sequence. If methyl affects genes that play an important role in suppressing a tumor, such as tumor suppressor genes, then it can cause a fatal result - cancer. Macrogen can correctly identify whether there is genome methylation using the Illumina microarray and give biological meaning through statistical analysis of the results. We have the most extensive experience in methylation chip analysis in Korea and provide a premium service that analyzes correlation based on methylation data and gene expression data.